Evidence Based Research Formulation

Fat
Systematic Review - 0.75g-3g / day reduce waist circumference

A systematic review and meta-analysis - modest reducing effect on body weight, BMI and fat mass

Burns more fat: Burned more fat during moderate exercise, and their muscles produced more energy during intense exercise.

Gut
Better insulin sensitivity: ALCAR improves insulin sensitivity in people who don’t process glucose well.

Energy Body
Systematic Review L-Carnitine Supplementation on Exercise-Induced Muscle Damage, improves muscle soreness and markers of muscle damage (CK, LDH, and Mb)
Reduces muscle fatigue: One study found that acetyl-L-carnitine decreases muscle fatigue in young people, too.

Tone
Builds muscle: ALCAR is a powerful anti-aging supplement if you’re older and want to build muscle. In older people, it decreases muscle fatigue and increases fat loss

Note: Systematic Reviews have been inconclusive and more research is needed, but research to date is promising and so we will continue to watch this space.

Energy Mind
Improves focus: Acetyl-L-carnitine improves attention, both in kids with ADHD and adults who struggle with mental fatigue.

More mental and physical energy: Older men and women who took ALCAR daily saw a significant boost to their physical and mental energy levels, as well as better overall cognitive ability.

Improves cognitive function: People with low carnitine levels see a major decrease in brain function. Significant advantage of L-carnitine in mild cognitive impairment (MCI) and mild (early) Alzheimer's disease (AD).

Fat
Systematic Review - showed that glutamine resulted in greater weight reduction

Systematic Review- glutamine supplementation could improve glycemic control and levels of incretins (such as GLP-1 and GIP) in diabetes mellitus.

Weight loss and possibly enhancing glucose metabolism Glutamine supplementation favors weight loss

Increase the levels of HGH: in your blood, the HGH (human growth hormone) plays a role in weight loss.

Reduces Waist Circumference in Overweight and Obese Humans

Gut
Gut Health Narrative Review: demonstrated that glutamine is one of the main beneficial amino acids. It plays an important role in gut microbiota and immunity.

Important role in maintaining Intestinal homeostasis: L-Glutamine is the most abundant and conditionally essential amino acid due to body’s inability to synthesize in adequate amounts during stressful conditions like trauma and sepsis

Reduced Cravings due to gut bacteria balances: Bacteroidetes to Firmicutes ratio in your gut system is a biomarker for obesity. L-Glutamine does to help fix the ratio of Firmicutes and Bacteroidetes in your system is to increase the levels of Bacteroidetes. In turn, this helps to stop the Firmicutes from taking over, and it can decrease the number of calories your body absorbs.

Low FODMAP diet & IBS symptoms indicates positive impact of Glutamine supplementation

Note: Systematic Reviews have been inconclusive and more research is needed.

Tone
Lean Body Tissue- Increases in Overweight People & Type 2 diabetes

Increased Lean body tissue in slightly overweight aging adults

Tone

Improving lean muscle-mass content Systematic Review - significantly improves sarcopenia (an age related, involuntary loss of skeletal muscle mass and strength) in elderly individuals 

Tone

Increases the muscle protein fractional synthetic rate Systematic Review 

Tone

Leucine triggers the rate and magnitude of muscle protein synthesis in response to supplementation

Tone

Beneficial effects on body weight, body mass index, and lean body mass Systematic Review in older persons in those subjects already prone to sarcopenia

Fat

Direct link to maintenance of glucose homeostasis by enhancing recycling of glucose via the glucose-alanine cycle

Gut

Maintenance of glucose homeostasis by enhancing recycling of glucose via the glucose-alanine cycle and a direct link to translational regulation of muscle protein synthesis through the insulin signaling cascade.

Gut

Supplementation results in beneficial effects in the adipose tissue, the skeletal muscle, and the intestine.

Gut

Chronic leucine supplementation lowers HbA1c level and improves glucose and insulin homeostasis in multiple mouse models of obesity and diabetes.

Energy Mind
Insuring sufficient amounts of iodine for achieving perfect cognitive performance

Information processing, fine motor skills, and visual problem solving are improved by iodine repletion in moderately iodine-deficient schoolchildren.

Food Safety ANZ Statements

Energy Mind: Necessary for normal neurological function

Energy Mind: Necessary for normal cognitive function

Energy Body: Necessary for normal energy metabolism

Tone: Contributes to the maintenance of normal skin

Stress
Systematic Review - B group vitamin supplementation may also benefit mood in healthy and at-risk individuals.

Energy Mind
B5 Deficiency can have depression, anxiety, memory loss 

Stress
Systematic Review The risk of depression reduction and intake of dietary vitamin B2, B6, and B12 were significant in females,

Fat
The functions of vitamin B6, it is evident that it is required to break down food and burn excess fat by stimulating the metabolism of lipids.

Stress
Vitamin B6 alone may reduce anxiety effectively in older women

Energy Mind
Vitamin B12 supplementation resulted in improved cognitive function, at least in the short term, in patients with vitamin B12 deficiency.

Energy Body
Vitamin B3 comprises a group of molecules that can act as precursors for the classical enzyme cofactor nicotinamide adenine dinucleotide (NAD). NAD is a central mediator of cellular energy metabolism and a crucial link between nutritional intake, cellular metabolism and health.

Food Safety ANZ Statements

Energy Body: B3 (Niacin) Necessary for normal energy release from food

Tone: B3 (Niacin) Necessary for normal structure and function of skin and mucous membranes

Mind: B3 (Niacin) Necessary for normal neurological function

Energy Body: B12 Necessary for Normal cell division

Energy Mind: B12 necessary for normal neurological (brain) structure and function

Energy Body: B12 contributes to normal energy metabolism

Gut: B12 contributes to normal homocysteine metabolism

Stress: B12 contribute to normal psychological function

Energy Body: B12 contributes to normal immune system function

Energy Body: B12 contributes to the reduction of tiredness and fatigue

Fat
Pantothenic acid (vitamin B5) is an essential precursor in the biosynthesis of Coenzyme A, which is required in the acyl-carrier protein involved in fatty acid synthesis.

Energy Mind
Pantothenic acid deficiency subjects complained of headache, fatigue, insomnia, and they reported excessive fatigue after their daily walk.

Energy Mind
Positive correlations exist between low dietary intakes of pantothenic acid (vitamin B5) with mood disorders.

Fat: Necessary for Normal Fat metabolism

Energy Body: Contributes to normal energy production

Energy Mind: Contributes to normal mental performance

Energy Mind: Contributes to the reduction of tiredness and fatigue

Energy Body
Unless you eat 1 Full cup of Carrots, Spinach, Pumpkin or Sweet Potato (or 30g of Liver) every day you are likely not getting your Vit A RDI and deficiency can cause fatigue. This is why we add a small amount 50% of RDI into our formulation to ensure your adequate intake is met. 

Energy Body
Fundamental role in mitochondrial energy homoeostasis and When vitamin A is deficient the production of energy is reduced by 30 percent.

Tone
Diet and skin disorders such as acne have been demonstrated to be linked and there is further research needed by good evidence with the link with Vitamin A

Food Safety ANZ Statements
Tone: Necessary for normal skin & mucous membrane structure and function

Energy Mind: Contributes to normal iron metabolism (highly important for women and iron deficiency is a big contributor to fatigue and low energy)

Energy Body: Contributes to normal immune system function

Stress
Systematic Review found folate reduced Hamilton Depression Rating Scale (HDRS) scores may have a potential role as a supplement to other treatment for depression over a longer period of time

Energy Body
Folic acid deficiency can cause irritability, forgetfulness, mental sluggishness

Food Safety ANZ Statements

Energy Mind: Contributes to normal homocysteine metabolism (this is an important normal function as Systematic Reviews have outlined abnormal high-levels - which are generally associated with vitamin deficiencies can lead to cognitive decline).

Energy Mind: Contributes to the reduction of tiredness and fatigue.

Energy Body: Contributes to normal immune system function.

Energy mind
A Cross-Sectional Study also outlines a significant association between vitamin-C plasma concentrations and performance on tasks involving attention, focus, working memory, decision speed, delayed and total recall, and recognition.

Energy Body
Systematic Review of IV Vitamin C on Fatigue observed a significant decrease in fatigue scores in the vitamin C group compared to the control group.

Stress
Systematic Review outlines vitamin C deficiency  is related to adverse mood and cognitive effects including; depression and cognitive impairment.

Tone
Systematic Review outlines Skin fibroblasts have an absolute dependence on vitamin C for the synthesis of collagen, and for the regulation of the collagen/elastin balance in the dermis.

Food Safety ANZ Statements
Energy Body: Contributes to the reduction of tiredness and fatigue

Gut: Contributes to normal iron absorption from food (highly important for women and iron deficiency is a big contributor to fatigue and low energy)

Energy Body: Necessary for normal neurological function

Energy Body: Contributes to the normal immune system function

Tone: Contributes to normal collagen formation for the normal function of skin

Energy Mind: Contributes to normal energy metabolism

Gut
Prebiotics increase Probiotics Systematic Review 

Gut

Probiotics improve gastrointestinal discomfort significant improvement of outcomes related to gastrointestinal discomfort in healthy adults.

Gut

Dietary prebiotic supplementation increased self-reported feelings of satiety (fullness) and significantly reduced postprandial (after food) glucose and insulin concentrations in healthy adults. Both impacts lead to reduction of cravings and overeating.

Fat

There are two main families of good bacteria in the gut: bacteroidetes and firmicutes. Body weight seems to be related to the balance of these two families of bacteria

Fat

Certain probiotics may inhibit the absorption of dietary fat

Fat
High fibre intake, particularly soluble fibre (Inulin our Prebiotic is a Soluble Fiber), is significantly related to lower levels of insulin resistance in women.Inulin-type fructans supplementation may provide a novel direction for improving the lipid profile and glucose metabolism.

Fat

Six months supplementation with probiotics resulted in significant weight reduction and improved small dense low-density lipoprotein-cholesterol (sdLDL-C) profiles

Fat

Intake of probiotics can have a modulating effect on body weight and BMI. Weight reduction was intensified by using probiotic

Fat

Reduced Cravings due to gut bacteria balances: Bacteroidetes to Firmicutes ratio in your gut system is a biomarker for obesity. The correlation between Firmicutes/Bacteroidetes ratio and obesity constitutes strong evidence arising from 30 years of research

Fat

Individuals with a low bacterial richness are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals.

Stress
A resistance to stress involves the nervous, endocrine, and immune systems. Adaptogens (plant extracts shown to enhance these responses) was conducted to determine efficacy in stress-induced fatigue and mental performance. 

The beneficial stress-protective effect of adaptogens is related to the regulation of homeostasis via several mechanisms.

Energy mind
Use of Schisandra for mental fatigue was assigned a grade B recommendation (note: grad B is considered moderately confident in the effect estimate),.

Energy body
Systematic Review outlines Schisandra plays a role in immunity and inflammation, promotes liver metabolism, improves fatigue, and regulates the function of steroid

A Systematic Review outline modest evidence of Ginseng as a Treatment for Fatigue for efficacy & Ginseng is a promising treatment for fatigue

Exhibits many pharmacological activities such antioxidant, antimicrobial, immune boosting, antitumor, hypoglycemic, hypolipidemic, wound healing, and antidiabetic

Antioxidant properties

Fat
Red pepper has beneficial effects on metabolic syndrome

Systematic Review & Meta-analysis significant effect on low density lipoprotein-cholesterol and marginally significant effect on body weight

Fat
Systematic Review of Cinnamon supplementation significantly affects obesity measures. It could be recommended as a weight-reducing supplement in obesity management.

systematic review and meta-analysis showed that cinnamon supplementation leads to significant but clinically modest decreases in BMI, weight, and WHR in patients with chronic conditions.Answer

Fat
Systematic Review The results indicated that the supplementation with ginger significantly decreased body weight.

Ginger also had a statistically significant positive effect on blood pressure, weight management and anti-inflammatory and antioxidant biomarkers.

Energy mind
Effectively relieves fatigue and depression condition and improves sleep quality in the patients with chronic fatigue syndrome

Note: Systematic Reviews have been inconclusive or limited to very high doses and more research is needed, but although research is varied it a promising contributing ingredient

Stress
Contains amino acid L-theanine, which can cross the blood-brain barrier, and increases the activity of the inhibitory neurotransmitter GABA, which has anti-anxiety effects.

Energy Mind
It also increases dopamine and the production of alpha waves in the brain, with potential uplift of learning and memory

Fat
The thermogenic properties and promotes fat oxidation and may play a role in the control of body composition via sympathetic activation of thermogenesis, fat oxidation, or both.

Gut
The Systematic Review findings suggest that vinegar can be effective in reducing postprandial glucose and insulin levels, indicating it could be considered as an adjunctive tool for improving glycemic control.

Fat
his meta-analysis review extends the evidence on the beneficial effects of vinegar on glycaemic control as measured by HbA1c and fasting blood glucose.

Energy mind

A systematic review outlines the impact of food-based anthocyanin consumption (blueberries are one of the richest forms) on both acute and long-term cognition appears promising.

The results of a randomized control trial, indicate that 3 months intervention with wild blueberry extract can facilitate better episodic memory performance over 6 months.

A systematic review outline the current evidence, that blueberries may improve some measures of cognitive performance when consumed for up to six months in duration.

After 12 wk of blueberry consumption, greater brain activity was detected using magnetic resonance imaging in healthy older adults during a cognitive challenge. The detection was associated with enhanced perfusion in regions mediating cognitive function.

Energy body
A systematic review of the research highlights improvement in anti-inflammatory biomarkers associated with blueberry intake is supported by observational (8), clinical (48), animal (87), and in vitro (114) evidence.

Gut
A systematic review and meta-analysis studies showed a significant improvement in systolic and diastolic blood pressure, triglycerides, total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL) and insulin levels. In conclusion, the data in this meta-analysis show that BB supplementation is a beneficial option for the management of MetS in humans.

A systematic review and meta-analysis of controlled trials outlines Grape Seed Extract (GSE) supplementation can remarkably modulate the body's redox system (redox reactions are essential for life as key transducers of cell signaling and metabolism), particularly through the inhibition of lipid peroxidation.

Fat
This meta-analysis demonstrated that GSE intake significantly reduced FPG, TC, LDL cholesterol, triglycerides, and CRP levels.

A meta-analysis findings demonstrate that grape seed extract exerted a beneficial impact on blood pressure, and this impact was more obvious in younger or obese subjects, as well as in patients with metabolic disorders. GSE may be beneficial for individuals with or at risk of cardiovascular disease because it may have hypotensive and HR-lowering properties.

Fat
A Systematic Review found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR.

The beneficial effects of “curcumin and zinc” co-supplementation was reported for the changes of some lipid profiles (TG, LDL, HDL, non-HDL, and HDL to LDL ratio), BMI, and weight.

Note: Not RCT - suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes.

However another systematic review outlines further research is required to determine the effect of turmeric on body weight. This is motivated by the fact that limited RCT studies exist on this.

Research suggests that curcumin may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and subsequent performance in active people. 

Gut

Citrus fruits and inflammaging: a systematic review outlines, Citrus fruits seem to possess capabilities in counteracting inflammation-based age-related diseases, thus representing a possible weapon to fight inflammaging.

Gut

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial

Fat

Regulated the biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity

Fat

Lemon juice significantly lowered the mean blood glucose concentration peak by 30% and delayed it more than 35 min. Lowering the pH of a meal can slow down starch digestion, the effect of lemon juice was similar to what has been repeatedly observed with vinegar, thus appears to be a effective strategy to reduce their glycemic impact.